The fifth edition of XAIB – Explainable Artificial Intelligence for Unveiling the Brain was held within the Congress Brain Informatics 2025, continuing a journey that began five years ago with a simple yet ambitious goal: to make Artificial Intelligence not only powerful but also understandable and trustworthy.
The Focus of XAIB2025
This year’s edition explored how explainability and uncertainty quantification can be combined to build AI systems that are both interpretable and reliable — two fundamental requirements for their translation into neuroscience and clinical practice.
XAIB2025 highlighted the importance of moving beyond accuracy, emphasizing reproducibility, transparency, and trust as the pillars of next-generation AI in medicine.
Invited Speakers
The session featured three outstanding invited speakers whose work is shaping the field of explainable and trustworthy AI:
- Valeriy Manokhin – Conformal Prediction for Trustworthy, Explainable AI
- Vincenzo Dentamaro – Deterministic Explainability with EVIDENCE and MuPAX Theories
- Felice Franchini – Beyond Stochastic XAI: Deterministic and Reproducible Explanations in Genomic Data
Their contributions provided complementary perspectives — from theoretical frameworks to methodological rigor and applications in biomedical data — offering a unified view of how explainability and reliability can coexist.
🎥 Watch the full recording of XAIB2025 here:






